Engineering human tissue models of cancer.
We develop vascularized, sex-specific microphysiological systems for disease modeling, with a particular interest in upper GI cancer
"How can we build physiologically relevant in-vitro tissue models that not only recapitulate human function, but also evolve through adaptive control?"
What we study
We develop microphysiological systems (MPS) that bridge in vitro assays and in vivo models for mechanistic studies of human cancer.
Our work integrates patient-derived tumour organoids with stromal representation to reconstruct the cancer microenvironment on-chip, supporting closed-loop, multidrug screening with adaptive dosing.
We build structured, functional tissue from living building blocks, directing how form and function emerge at the organ scale.
Using droplet microfluidics such as ReSCUE, we generate and recover shape-defined cancer organoids and assemble them into macroscale constructs, tuning the biomechanical environment to steer organogenesis.
We use computational fluid dynamics and automated microfluidic setups to design, operate, and refine cancer-on-chip platforms in a closed loop.
Digital-twin CFD models predict device geometry before fabrication; self-driving fluidic control sustains perfusion, dosing, and sampling with minimal manual intervention.